Accumulation of duct cells with activated YAP parallels fibrosis progression in NonAlcoholic Fatty Liver Disease

BACKGROUND & AIMS: Mechanisms that regulate regeneration of injured livers are complex. YAP, a stem-cell associated factor, controls liver growth in healthy adult mice. Increasing nuclear localization of YAP triggers accumulation of reactive-appearing ductular cells (YAP+RDC) with liver progenit...

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Publicat a:J Hepatol
Autors principals: Machado, Mariana Verdelho, Michelotti, Gregory Alexander, de Almeida, Thiago Pereira, Xie, Guanhua, Premont, Richard, Cortez-Pinto, Helena, Diehl, Anna Mae
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575842/
https://ncbi.nlm.nih.gov/pubmed/26070409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.05.031
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