Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis

INTRODUCTION: Interleukin-1β (IL-1β) is a major inflammatory cytokine, produced predominantly by innate immune cells through NLRP3-inflammasome activation. Both intrinsic and extrinsic danger signals may activate NLRP3. Genetic variations in NLRP3-inflammasome components have been reported to influe...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Choulaki, Christianna, Papadaki, Garyfallia, Repa, Argyro, Kampouraki, Eleni, Kambas, Konstantinos, Ritis, Konstantinos, Bertsias, George, Boumpas, Dimitrios T., Sidiropoulos, Prodromos
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575443/
https://ncbi.nlm.nih.gov/pubmed/26385789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0775-2
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