Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Progressive supranuclear palsy (PSP) is a movement disorder characterized by tau neuropathology where the underlying mechanism is unknown. A single nucleotide polymorphism (rs1768208 C/T) has been identified as a strong risk factor for PSP. Here, we identified a much higher T-allele occurrence and i...

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Publicado en:Neuron
Main Authors: Zhao, Yingjun, Tseng, I-Chu, Heyser, Charles J., Rockenstein, Edward, Mante, Michael, Adame, Anthony, Zheng, Qiuyang, Huang, Timothy, Wang, Xin, Arslan, Pharhad E., Chakrabarty, Paramita, Wu, Chengbiao, Bu, Guojun, Mobley, William C., Zhang, Yun-wu, George-Hyslop, Peter St., Masliah, Eliezer, Fraser, Paul, Xu, Huaxi
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575284/
https://ncbi.nlm.nih.gov/pubmed/26335643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.08.020
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