Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit

AIMS: The long-term disposition of tacrolimus following kidney transplantation is characterized by a gradual decrease in dose requirements and increase in dose-corrected exposure. This phenomenon has been attributed to a progressive decline in cytochrome P450 3A4 (CYP3A4) activity, although this has...

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Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: de Jonge, Hylke, Vanhove, Thomas, de Loor, Henriëtte, Verbeke, Kristin, Kuypers, Dirk R J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
Soggetti:
Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574839/
https://ncbi.nlm.nih.gov/pubmed/26114223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12703
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