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Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug–drug interaction studies
AIMS: The regulatory prohibition of ketoconazole as a CYP3A index inhibitor in drug–drug interaction (DDI) studies has compelled consideration of alternative inhibitors. METHODS: The biomedical literature was searched to identify DDI studies in which oral midazolam (MDZ) was the victim, and the inhi...
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| Pubblicato in: | Br J Clin Pharmacol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley & Sons, Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4574820/ https://ncbi.nlm.nih.gov/pubmed/25923589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12668 |
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