In vivo analysis of trypanosome mitochondrial RNA function by artificial site-specific RNA endonuclease-mediated knockdown

Trypanosomes possess a unique mitochondrial genome called the kinetoplast DNA (kDNA). Many kDNA genes encode pre-mRNAs that must undergo guide RNA-directed editing. In addition, alternative mRNA editing gives rise to diverse mRNAs and several kDNA genes encode open reading frames of unknown function...

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Bibliographic Details
Published in:RNA
Main Authors: Szempruch, Anthony J., Choudhury, Rajarshi, Wang, Zefeng, Hajduk, Stephen L.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574754/
https://ncbi.nlm.nih.gov/pubmed/26264591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.052084.115
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