Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages

Death Receptor 5 (DR5) agonists demonstrate anti-tumor activity in preclinical models but have yet to demonstrate robust clinical responses. A key limitation may be the lack of patient selection strategies to identify those most likely to respond to treatment. To overcome this limitation, we screene...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Reddy, Anupama, Growney, Joseph D., Wilson, Nick S., Emery, Caroline M., Johnson, Jennifer A., Ward, Rebecca, Monaco, Kelli A., Korn, Joshua, Monahan, John E., Stump, Mark D., Mapa, Felipa A., Wilson, Christopher J., Steiger, Janine, Ledell, Jebediah, Rickles, Richard J., Myer, Vic E., Ettenberg, Seth A., Schlegel, Robert, Sellers, William R., Huet, Heather A., Lehár, Joseph
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574744/
https://ncbi.nlm.nih.gov/pubmed/26378449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138486
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