Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer’s disease

BACKGROUND: Pathological features of Alzheimer’s disease (AD) include aggregation of amyloid beta (Aβ) and tau protein. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been implicated in the toxicity of aggregated Aβ. It remains unclear whether MIF affects hyperphosphor...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Li, Shu-Qin, Yu, Yang, Han, Jin-Zhao, Wang, Ding, Liu, Jin, Qian, Feng, Fan, Guo-Huang, Bucala, Richard, Ye, Richard D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574615/
https://ncbi.nlm.nih.gov/pubmed/26382037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0396-3
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