Evaluation of the efficiency of tumor and tissue delivery of carrier-mediated agents (CMA) and small molecule (SM) agents in mice using a novel pharmacokinetic (PK) metric: relative distribution index over time (RDI-OT)

The pharmacokinetics (PK) of carrier-mediated agents (CMA) is dependent upon the carrier system. As a result, CMA PK differs greatly from the PK of small molecule (SM) drugs. Advantages of CMAs over SMs include prolonged circulation time in plasma, increased delivery to tumors, increased antitumor r...

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Bibliografiske detaljer
Udgivet i:J Nanopart Res
Main Authors: Madden, Andrew J., Rawal, Sumit, Sandison, Katie, Schell, Ryan, Schorzman, Allison, Deal, Allison, Feng, Lan, Ma, Ping, Mumper, Russell, DeSimone, Joseph, Zamboni, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574509/
https://ncbi.nlm.nih.gov/pubmed/26392803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11051-014-2662-1
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