Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.

To combat bacterial infection, phagocytes generate superoxide (O2-) and other microbicidal oxygen radicals. NADPH oxidase, the enzyme responsible for O2- synthesis, is deficient in chronic granulomatous disease (CGD) patients. Although O2- generation is accompanied by a large burst of metabolic acid...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Nanda, A, Grinstein, S, Curnutte, J T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45745/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8421713/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.2.760
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