Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli

The transcription factor NFκB is a central regulator of inflammation and genome-wide association studies in subjects with autoimmune disease have identified a number of variants within the NFκB signaling cascade. In addition, causal variant fine-mapping has demonstrated that autoimmune disease susce...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Housley, William J., Fernandez, Salvador D., Vera, Kenneth, Murikinati, Sasidhar R., Grutzendler, Jaime, Cuerdon, Nicole, Glick, Laura, De Jager, Phillip L., Mitrovic, Mitja, Cotsapas, Chris, Hafler, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574294/
https://ncbi.nlm.nih.gov/pubmed/26062845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa9223
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