A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

Certain missense mutations in optineurin/OPTN and amplification of TBK1 are associated with normal tension glaucoma. A glaucoma-associated variant of OPTN, M98K, induces autophagic degradation of transferrin receptor (TFRC) and death in retinal cells. Here, we have explored the role of Tbk1 in M98K-...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Sirohi, Kapil, Kumari, Asha, Radha, Vegesna, Swarup, Ghanshyam
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574030/
https://ncbi.nlm.nih.gov/pubmed/26376340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138289
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires