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M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

Mutations in the autophagy receptor OPTN/optineurin are associated with the pathogenesis of glaucoma and amyotrophic lateral sclerosis, but the underlying molecular basis is poorly understood. The OPTN variant, M98K has been described as a risk factor for normal tension glaucoma in some ethnic group...

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Detalhes bibliográficos
Main Authors: Sirohi, Kapil, Chalasani, Madhavi Latha Somaraju, Sudhakar, Cherukuri, Kumari, Asha, Radha, Vegesna, Swarup, Ghanshyam
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627667/
https://ncbi.nlm.nih.gov/pubmed/23357852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.23458
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