Small molecule NSC59984 restores p53 pathway signaling and anti-tumor effects against colorectal cancer via p73 activation and degradation of mutant p53

The tumor suppressor p53 prevents cancer development via initiating cell cycle arrest, cell death, repair, or anti-angiogenesis processes. Over 50% of human cancers harbor cancer-causing mutant p53. p53 mutations not only abrogate its tumor suppressor function, but also endow mutant p53 with a gain-...

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Publicado no:Cancer Res
Main Authors: Zhang, Shengliang, Zhou, Lanlan, Hong, Bo, van den Heuvel, A. Pieter J., Prabhu, Varun V., Warfel, Noel A., Kline, Christina Leah B., Dicker, David T., Kopelovich, Levy, El-Deiry, Wafik S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573895/
https://ncbi.nlm.nih.gov/pubmed/26294215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1079
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