SLFN11 is a transcriptional target of EWS-FLI1 and a determinant of drug response in Ewing’s sarcoma

PURPOSE: SLFN11 was identified as a critical determinant of response to DNA targeted therapies by analyzing gene expression and drug sensitivity of NCI-60 and CCLE datasets. However, how SLFN11 is regulated in cancer cells remained unknown. Ewing’s sarcoma (ES), which is characterized by the chimeri...

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Published in:Clin Cancer Res
Main Authors: Tang, Sai-Wen, Bilke, Sven, Cao, Liang, Murai, Junko, Sousa, Fabricio G., Yamade, Mihoko, Rajapakse, Vinodh, Varma, Sudhir, Helman, Lee J., Khan, Javed, Meltzer, Paul S., Pommier, Yves
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573368/
https://ncbi.nlm.nih.gov/pubmed/25779942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2112
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