Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages

Runs of homozygosity (ROHs) are recognized signature of recessive inheritance. Contributions of ROHs to the genetic architecture of coronary artery disease and regulation of gene expression in cells relevant to atherosclerosis are not known. Our combined analysis of 24,320 individuals from 11 popula...

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izdano v:Am J Hum Genet
Main Authors: Christofidou, Paraskevi, Nelson, Christopher P., Nikpay, Majid, Qu, Liming, Li, Mingyao, Loley, Christina, Debiec, Radoslaw, Braund, Peter S., Denniff, Matthew, Charchar, Fadi J., Arjo, Ares Rocanin, Trégouët, David-Alexandre, Goodall, Alison H., Cambien, Francois, Ouwehand, Willem H., Roberts, Robert, Schunkert, Heribert, Hengstenberg, Christian, Reilly, Muredach P., Erdmann, Jeanette, McPherson, Ruth, König, Inke R., Thompson, John R., Samani, Nilesh J., Tomaszewski, Maciej
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573243/
https://ncbi.nlm.nih.gov/pubmed/26166477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.06.001
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