Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice

We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The liver is the primary site of CRP synthesis in humans and in CRPtg mi...

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Detalhes bibliográficos
Publicado no:Autoimmune Dis
Main Authors: Wright, Tyler T, Jimenez, Rachel V., Morgan, Todd E., Bali, Namrata, Hou, Xiaogang, McCrory, Mark A., Finch, Caleb E., Szalai, Alexander J.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573232/
https://ncbi.nlm.nih.gov/pubmed/26421184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/640171
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