Targeted Disruption of the β(2)-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells

Human embryonic stem cells (hESCs) are a promising source of cells for tissue regeneration, yet histoincompatibility remains a major challenge to their clinical application. Because the human leukocyte antigen class I (HLA-I) molecules are the primary mediators of immune rejection, we hypothesized t...

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Dettagli Bibliografici
Pubblicato in:Stem Cells Transl Med
Autori principali: Wang, Dachun, Quan, Yuan, Yan, Qing, Morales, John E., Wetsel, Rick A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AlphaMed Press 2015
Soggetti:
Tissue Engineering and Regenerative Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572902/
https://ncbi.nlm.nih.gov/pubmed/26285657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0049
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