Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

BACKGROUND: Pallido-ponto-nigral degeneration (PPND), a major subtype of frontotemporal dementia with parkinsonism related to chromosome 17 (FTDP-17), is a progressive and terminal neurodegenerative disease caused by c.837 T > G mutation in the MAPT gene encoding microtubule-associated protein ta...

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Publicado en:Mol Neurodegener
Main Authors: Wren, Melissa C., Zhao, Jing, Liu, Chia-Chen, Murray, Melissa E., Atagi, Yuka, Davis, Mary D., Fu, Yuan, Okano, Hirotaka J., Ogaki, Kotaro, Strongosky, Audrey J., Tacik, Pawel, Rademakers, Rosa, Ross, Owen A., Dickson, Dennis W., Wszolek, Zbigniew K., Kanekiyo, Takahisa, Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572645/
https://ncbi.nlm.nih.gov/pubmed/26373282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0042-7
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