Nuclear Translocation of Calcium/Calmodulin-dependent Protein Kinase IIδ3 Promoted by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic Factor Expression in Dopaminergic Neurons

We have reported previously that dopamine D(2) receptor stimulation activates calcium/calmodulin-dependent protein kinase II (CaMKII) δ3, a CaMKII nuclear isoform, increasing BDNF gene expression. However, the mechanisms underlying that activity remained unclear. Here we report that CaMKIIδ3 is deph...

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Vydáno v:J Biol Chem
Hlavní autoři: Shioda, Norifumi, Sawai, Masahiro, Ishizuka, Yuta, Shirao, Tomoaki, Fukunaga, Kohji
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571889/
https://ncbi.nlm.nih.gov/pubmed/26163515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664920
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