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High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells
We previously showed that ADAM17 mediates high glucose-induced matrix production by kidney mesangial cells. ADAM17 expression is increased in diabetic kidneys, suggesting that its up-regulation may augment high glucose profibrotic responses. We thus studied the effects of high glucose on ADAM17 gene...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4571884/ https://ncbi.nlm.nih.gov/pubmed/26175156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.651604 |
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