Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer

BACKGROUND. The CHER-LOB randomized phase II study showed that the combination of lapatinib and trastuzumab plus chemotherapy increases the pathologic complete remission (pCR) rate compared with chemotherapy plus either trastuzumab or lapatinib. A biomarker program was prospectively planned to ident...

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Bibliographic Details
Published in:Oncologist
Main Authors: Guarneri, Valentina, Dieci, Maria Vittoria, Frassoldati, Antonio, Maiorana, Antonino, Ficarra, Guido, Bettelli, Stefania, Tagliafico, Enrico, Bicciato, Silvio, Generali, Daniele Giulio, Cagossi, Katia, Bisagni, Giancarlo, Sarti, Samanta, Musolino, Antonino, Ellis, Catherine, Crescenzo, Rocco, Conte, PierFranco
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2015
Subjects:
Breast Cancer
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571802/
https://ncbi.nlm.nih.gov/pubmed/26245675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0138
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