Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation

Vasoconstriction mediated by the highly selective alpha-2 adrenoceptor agonist dexmedetomidine leads to transiently increased blood pressure and severe hypertension. The dexmedetomidine-induced contraction involves the protein kinase C (PKC)-mediated pathway. However, the main PKC isoform involved i...

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Detalhes bibliográficos
Publicado no:Int J Med Sci
Main Authors: Yu, Jongsun, Ok, Seong-Ho, Kim, Won Ho, Cho, Hyunhoo, Park, Jungchul, Shin, il-Woo, Lee, Heon Keun, Chung, Young-Kyun, Choi, Mun-Jeoung, Kwon, Seong-Chun, Sohn, Ju-Tae
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571550/
https://ncbi.nlm.nih.gov/pubmed/26392810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.11952
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