Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABA(A) Receptors on Nonpyramidal Cells

Previous experiments using genetic and pharmacological manipulations have provided strong evidence that etomidate impairs synaptic plasticity and memory by modulating α5-subunit containing GABA(A) receptors (α5-GABA(A)Rs). Because α5-GABA(A)Rs mediate tonic inhibition (TI) in hippocampal CA1 pyramid...

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Vydáno v:J Neurosci
Hlavní autoři: Rodgers, F. Clifford, Zarnowska, Ewa D., Laha, Kurt T., Engin, Elif, Zeller, Anja, Keist, Ruth, Rudolph, Uwe, Pearce, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571505/
https://ncbi.nlm.nih.gov/pubmed/26134653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0315-15.2015
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