Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor

Enhancement of tonic inhibition mediated by extrasynaptic α5-subunit containing GABA(A) receptors (GABA(A)Rs) has been proposed as the mechanism by which a variety of anesthetics, including the general anesthetic etomidate, impair learning and memory. Since α5 subunits preferentially partner with β3...

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Publicado en:Neuropharmacology
Main Authors: Zarnowska, ED, Rodgers, FC, Oh, I, Rau, V, Lor, C, Laha, KT, Jurd, R, Rudolph, U, Eger, EI, Pearce, RA
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387092/
https://ncbi.nlm.nih.gov/pubmed/25680234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.01.011
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