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A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function?
[Image: see text] Uncontrolled inflammation or oxidative stress generates electron-deficient species that oxidize the genome increasing its instability in cancer. The G-quadruplex (G4) sequences regulating the c-MYC, KRAS, VEGF, BCL-2, HIF-1α, and RET oncogenes, as examples, are targets for oxidatio...
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| Publicado no: | ACS Cent Sci |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2015
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4571166/ https://ncbi.nlm.nih.gov/pubmed/26405692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00202 |
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