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Activators of protein kinase C depolarize insulin-secreting cells by closing K+ channels.

Carbohydrate stimuli of insulin secretion depolarize the pancreatic B cell and the B-cell line RINm5F by inhibiting ATP-sensitive K+ channels. We examined the possibility that this effect is mediated by activation of protein kinase C. In RINm5F cells, the triose D-glyceraldehyde evoked a rapid incre...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Wollheim, C B, Dunne, M J, Peter-Riesch, B, Bruzzone, R, Pozzan, T, Petersen, O H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1988
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC457113/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3056715/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03090.x
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