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Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation

BACKGROUND: Genome wide-association studies have successfully identified several hundred independent loci harboring common cancer susceptibility alleles that are distinct from the more than 110 cancer predisposition genes. The latter are generally characterized by disruptive mutations in coding gene...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Machiela, Mitchell J., Ho, Brian M., Fisher, Victoria A., Hua, Xing, Chanock, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571124/
https://ncbi.nlm.nih.gov/pubmed/26374197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0755-5
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