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Functionality of Class A and Class B J-protein Co-chaperones with Hsp70

At their C-termini, cytosolic Hsp70s have an EEVD tetrapeptide that interacts with J-protein co-chaperones of the B, but not A, class. This interaction is required for partnering with yeast B-type J-proteins in protein folding. Here we report conservation of this feature. Human B-type J-proteins als...

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Veröffentlicht in:FEBS Lett
Hauptverfasser: Yu, Hyun Young, Ziegelhoffer, Thomas, Craig, Elizabeth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570866/
https://ncbi.nlm.nih.gov/pubmed/26247431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.07.040
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