Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age

IMPORTANCE: Individuals in the presymptomatic stage of Alzheimer disease (AD) are increasingly being targeted for AD secondary prevention trials. How early during the normal life span underlying AD pathologies begin to develop, their patterns of change over time, and their relationship with future c...

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Publicado en:JAMA Neurol
Autores principales: Sutphen, Courtney L., Jasielec, Mateusz S., Shah, Aarti R., Macy, Elizabeth M., Xiong, Chengjie, Vlassenko, Andrei G., Benzinger, Tammie L. S., Stoops, Erik E. J., Vanderstichele, Hugo M. J., Brix, Britta, Darby, Heather D., Vandijck, Manu L. J., Ladenson, Jack H., Morris, John C., Holtzman, David M., Fagan, Anne M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570860/
https://ncbi.nlm.nih.gov/pubmed/26147946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1285
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