Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age

IMPORTANCE: Individuals in the presymptomatic stage of Alzheimer disease (AD) are increasingly being targeted for AD secondary prevention trials. How early during the normal life span underlying AD pathologies begin to develop, their patterns of change over time, and their relationship with future c...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Sutphen, Courtney L., Jasielec, Mateusz S., Shah, Aarti R., Macy, Elizabeth M., Xiong, Chengjie, Vlassenko, Andrei G., Benzinger, Tammie L. S., Stoops, Erik E. J., Vanderstichele, Hugo M. J., Brix, Britta, Darby, Heather D., Vandijck, Manu L. J., Ladenson, Jack H., Morris, John C., Holtzman, David M., Fagan, Anne M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570860/
https://ncbi.nlm.nih.gov/pubmed/26147946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1285
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