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Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age

IMPORTANCE: Individuals in the presymptomatic stage of Alzheimer disease (AD) are increasingly being targeted for AD secondary prevention trials. How early during the normal life span underlying AD pathologies begin to develop, their patterns of change over time, and their relationship with future c...

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Dettagli Bibliografici
Pubblicato in:JAMA Neurol
Autori principali: Sutphen, Courtney L., Jasielec, Mateusz S., Shah, Aarti R., Macy, Elizabeth M., Xiong, Chengjie, Vlassenko, Andrei G., Benzinger, Tammie L. S., Stoops, Erik E. J., Vanderstichele, Hugo M. J., Brix, Britta, Darby, Heather D., Vandijck, Manu L. J., Ladenson, Jack H., Morris, John C., Holtzman, David M., Fagan, Anne M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570860/
https://ncbi.nlm.nih.gov/pubmed/26147946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1285
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