Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age

IMPORTANCE: Individuals in the presymptomatic stage of Alzheimer disease (AD) are increasingly being targeted for AD secondary prevention trials. How early during the normal life span underlying AD pathologies begin to develop, their patterns of change over time, and their relationship with future c...

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Bibliografiset tiedot
Julkaisussa:JAMA Neurol
Päätekijät: Sutphen, Courtney L., Jasielec, Mateusz S., Shah, Aarti R., Macy, Elizabeth M., Xiong, Chengjie, Vlassenko, Andrei G., Benzinger, Tammie L. S., Stoops, Erik E. J., Vanderstichele, Hugo M. J., Brix, Britta, Darby, Heather D., Vandijck, Manu L. J., Ladenson, Jack H., Morris, John C., Holtzman, David M., Fagan, Anne M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570860/
https://ncbi.nlm.nih.gov/pubmed/26147946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1285
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