Variants of human tissue-type plasminogen activator that lack specific structural domains of the heavy chain.

The heavy chain of tissue plasminogen activator (t-PA) consists of four domains [finger, epidermal-growth-factor (EGF)-like, kringle 1 and kringle 2] that are homologous to similar domains present in other proteins. To assess the contribution of each of the domains to the biological properties of th...

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Publicado en:EMBO J
Autores principales: Gething, M J, Adler, B, Boose, J A, Gerard, R D, Madison, E L, McGookey, D, Meidell, R S, Roman, L M, Sambrook, J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC457063/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2846282/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03127.x
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