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A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors

The interaction between the eukaryotic translation initiation factor 4E (eIF4E) and eIF4E binding proteins (4E-BP) is a promising template for the inhibition of eIF4E and the treatment of diseases such as cancer and a spectrum of autism disorders, including the Fragile X syndrome (FXS). Here, we rep...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Protein Sci
Päätekijät: Di Marino, Daniele, D'Annessa, Ilda, Tancredi, Holly, Bagni, Claudia, Gallicchio, Emilio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley & Sons, Ltd 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570532/
https://ncbi.nlm.nih.gov/pubmed/26013047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2708
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