Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

The cellular proteostasis network integrates the protein folding and clearance machineries in multiple sub-cellular compartments of the eukaryotic cell. The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins. A distinctive feature of the ER is its tigh...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Kirstein, Janine, Morito, Daisuke, Kakihana, Taichi, Sugihara, Munechika, Minnen, Anita, Hipp, Mark S, Nussbaum-Krammer, Carmen, Kasturi, Prasad, Hartl, F Ulrich, Nagata, Kazuhiro, Morimoto, Richard I
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570520/
https://ncbi.nlm.nih.gov/pubmed/26228940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591711
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