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Nuclear export of ubiquitinated proteins via the UBIN-POST system

Although mechanisms for protein homeostasis in the cytosol have been studied extensively, those in the nucleus remain largely unknown. Here, we identified that a protein complex mediates export of polyubiquitinated proteins from the nucleus to the cytosol. UBIN, a ubiquitin-associated (UBA) domain-c...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Hirayama, Shoshiro, Sugihara, Munechika, Morito, Daisuke, Iemura, Shun-ichiro, Natsume, Tohru, Murata, Shigeo, Nagata, Kazuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939056/
https://ncbi.nlm.nih.gov/pubmed/29666234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711017115
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