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Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled
Type I phosphatidylinositol phosphate kinase (PIP5K1) phosphorylates the head group of phosphatidylinositol 4-phosphate (PtdIns4P) to generate PtdIns4,5P(2), which plays important roles in a wide range of cellular functions including Wnt signalling. However, the lack of its structural information ha...
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Publicado no: | Nat Commun |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Pub. Group
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570271/ https://ncbi.nlm.nih.gov/pubmed/26365782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9205 |
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