Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression

Therapeutic vaccinations against cancer are still largely ineffective. Major caveats are inefficient delivery of tumor antigens to dendritic cells (DCs) and excessive immune suppression by Foxp3(+) regulatory T cells (Tregs), resulting in defective T cell priming and failure to induce tumor regressi...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Unger, Wendy WJ, Mayer, Christian T, Engels, Steef, Hesse, Christina, Perdicchio, Maurizio, Puttur, Franz, Streng-Ouwehand, Ingeborg, Litjens, Manja, Kalay, Hakan, Berod, Luciana, Sparwasser, Tim, van Kooyk, Yvette
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570108/
https://ncbi.nlm.nih.gov/pubmed/26405564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.970462
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