Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis

AT2433 from Actinomadura melliaura is an indolocarbazole antitumor antibiotic structurally distinguished by its unique aminodideoxypentose-containing disaccharide moiety. The corresponding sugar nucleotide-based biosynthetic pathway for this unusual sugar derives from comparative genomics where AtmS...

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Bibliographic Details
Published in:Proteins
Main Authors: Singh, Shanteri, Kim, Youngchang, Wang, Fengbin, Bigelow, Lance, Endres, Michael, Kharel, Madan K., Babnigg, Gyorgy, Bingman, Craig A., Joachimiak, Andrzej, Thorson, Jon S., Phillips, George N.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570032/
https://ncbi.nlm.nih.gov/pubmed/26061967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24844
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