Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate

CalE6 from Micromonospora echinospora is a (pyridoxal 5′ phosphate) PLP-dependent methionine γ-lyase involved in the biosynthesis of calicheamicins. We report the crystal structure of a CalE6 2-(N-morpholino)ethanesulfonic acid complex showing ligand-induced rotation of Tyr100, which stacks with PLP...

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Detalhes bibliográficos
Publicado no:Struct Dyn
Main Authors: Cao, Hongnan, Tan, Kemin, Wang, Fengbin, Bigelow, Lance, Yennamalli, Ragothaman M., Jedrzejczak, Robert, Babnigg, Gyorgy, Bingman, Craig A., Joachimiak, Andrzej, Kharel, Madan K., Singh, Shanteri, Thorson, Jon S., Phillips, George N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Crystallographic Association 2016
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ARTICLES
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851618/
https://ncbi.nlm.nih.gov/pubmed/27191010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4948539
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