Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism

The OPRM1 A118G polymorphism is the most widely studied μ-opioid receptor (MOR) variant. Although its involvement in acute alcohol effects is well characterized, less is known about the extent to which it alters responses to opioids. Prior work has shown that both electrophysiological and analgesic...

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Bibliografiske detaljer
Udgivet i:Neuropsychopharmacology
Main Authors: Robinson, J Elliott, Vardy, Eyal, DiBerto, Jeffrey F, Chefer, Vladimir I, White, Kate L, Fish, Eric W, Chen, Meng, Gigante, Eduardo, Krouse, Michael C, Sun, Hui, Thorsell, Annika, Roth, Bryan L, Heilig, Markus, Malanga, C J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569952/
https://ncbi.nlm.nih.gov/pubmed/25881115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.109
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