Pharmacological Consequence of the A118G Mu Opioid Receptor Polymorphism on Morphine- and Fentanyl-mediated Modulation of Ca(2+) Channels in Humanized Mouse Sensory Neurons

BACKGROUND: The most common functional single nucleotide polymorphism of the human OPRM1 gene, A118G, has been shown to be associated with inter-individual differences in opioid analgesic requirements, particularly with morphine, in patients with acute postoperative pain. The purpose of the present...

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Hlavní autoři: Mahmoud, Saifeldin, Thorsell, Annika, Sommer, Wolfgang H., Heilig, Markus, Holgate, Joan K., Bartlett, Selena E., Ruiz-Velasco, Victor
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203255/
https://ncbi.nlm.nih.gov/pubmed/21926562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318231fc11
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