Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age

Expression of brain-derived neurotrophic factor (BDNF) and somatostatin (SST) mRNAs in the brain decreases progressively and robustly with age, and lower BDNF and SST expression in the brain has been observed in many brain disorders. BDNF is known to regulate SST expression; however, the mechanisms...

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Publicat a:Neuropsychopharmacology
Autors principals: McKinney, Brandon C, Lin, Chien-Wei, Oh, Hyunjung, Tseng, George C, Lewis, David A, Sibille, Etienne
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569950/
https://ncbi.nlm.nih.gov/pubmed/25881116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.107
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