Development of high-yield influenza A virus vaccine viruses

Vaccination is one of the most cost-effective ways to prevent infection. Influenza vaccines propagated in cultured cells are approved for use in humans, but their yields are often suboptimal. Here, we screened A/Puerto Rico/8/34 (PR8) virus mutant libraries to develop vaccine backbones (defined here...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ping, Jihui, Lopes, Tiago J.S., Nidom, Chairul A., Ghedin, Elodie, Macken, Catherine A., Fitch, Adam, Imai, Masaki, Maher, Eileen A., Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569720/
https://ncbi.nlm.nih.gov/pubmed/26334134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9148
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