A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine (LK), stimulates autophagy in RG2 glioma and SH-...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Harris-White, Marni E., Ferbas, Kathie G., Johnson, Ming F., Eslami, Pirooz, Poteshkina, Aleksandra, Venkova, Kalina, Christov, Alexandar, Hensley, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569546/
https://ncbi.nlm.nih.gov/pubmed/25779968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.03.007
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