Resistance-Associated NS5A Variants of Hepatitis C Virus Are Susceptible to Interferon-Based Therapy

BACKGROUND & AIMS: The presence of resistance-associated variants (RAVs) of hepatitis C virus (HCV) attenuates the efficacy of direct acting antivirals (DAAs). The objective of this study was to characterize the susceptibility of RAVs to interferon-based therapy. METHODS: Direct and deep sequenc...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Itakura, Jun, Kurosaki, Masayuki, Higuchi, Mayu, Takada, Hitomi, Nakakuki, Natsuko, Itakura, Yoshie, Tamaki, Nobuharu, Yasui, Yutaka, Suzuki, Shoko, Tsuchiya, Kaoru, Nakanishi, Hiroyuki, Takahashi, Yuka, Maekawa, Shinya, Enomoto, Nobuyuki, Izumi, Namiki
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569333/
https://ncbi.nlm.nih.gov/pubmed/26368554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138060
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