Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells

BACKGROUND: Tumor necrosis factor (TNF)-α and matrix metalloproteinases (MMPs) are elevated in pleural fluids of tuberculous pleuritis (TBP) where pleural mesothelial cells (PMCs) conduct the first-line defense against Mycobacterium tuberculosis (MTB). However, the clinical implication of TNF-α and...

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Udgivet i:PLoS One
Main Authors: Chen, Wei-Lin, Sheu, Joen-Rong, Chen, Ray-Jade, Hsiao, Shih-Hsin, Hsiao, Che-Jen, Chou, Yung-Chen, Chung, Chi-Li, Hsiao, George
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569295/
https://ncbi.nlm.nih.gov/pubmed/26367274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137979
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