A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression

BACKGROUND: The high heritability of plasma renin activity was confirmed in recent investigations. A variation located near the strong enhancer of the human renin gene (REN), C-5312T, has been shown to have different transcription activity levels depending on its allele: the 5312T allele shows trans...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Makino, Yasukazu, Konoshita, Tadashi, Omori, Atsuhito, Maegawa, Nobuhiro, Nakaya, Takahiro, Ichikawa, Mai, Yamamoto, Katsushi, Wakahara, Shigeyuki, Ishizuka, Tamotsu, Onoe, Tamehito, Nakamura, Hiroyuki
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569054/
https://ncbi.nlm.nih.gov/pubmed/26366736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137469
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