A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression

BACKGROUND: The high heritability of plasma renin activity was confirmed in recent investigations. A variation located near the strong enhancer of the human renin gene (REN), C-5312T, has been shown to have different transcription activity levels depending on its allele: the 5312T allele shows trans...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Makino, Yasukazu, Konoshita, Tadashi, Omori, Atsuhito, Maegawa, Nobuhiro, Nakaya, Takahiro, Ichikawa, Mai, Yamamoto, Katsushi, Wakahara, Shigeyuki, Ishizuka, Tamotsu, Onoe, Tamehito, Nakamura, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569054/
https://ncbi.nlm.nih.gov/pubmed/26366736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137469
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