Silencing the α(2) subunit of GABA(A) receptors in rat dorsal root ganglia reveals its major role in antinociception post-traumatic nerve injury

BACKGROUND: Neuropathic pain is likely the result of repetitive high frequency bursts of peripheral afferent activity leading to long-lasting changes in synaptic plasticity in the spinal dorsal horn (DH). Drugs that promote GABA activity in the DH provide partial relief of neuropathic symptoms. We e...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Obradović, Aleksandar LJ, Scarpa, Joseph, Osuru, Hari P, Weaver, Janelle L, Park, Ji-Yong, Pathirathna, Sriyani, Peterkin, Alexander, Lim, Yunhee, Jagodic, Miljenko M, Todorovic, Slobodan M, Jevtovic-Todorovic, Vesna
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568754/
https://ncbi.nlm.nih.gov/pubmed/26164299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000767
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