Effect of aging on muscle mitochondrial substrate utilization in humans

Previous studies have implicated age-associated reductions in mitochondrial oxidative phosphorylation activity in skeletal muscle as a predisposing factor for intramyocellular lipid (IMCL) accumulation and muscle insulin resistance (IR) in the elderly. To further investigate potential alterations in...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Petersen, Kitt Falk, Morino, Katsutaro, Alves, Tiago C., Kibbey, Richard G., Dufour, Sylvie, Sono, Saki, Yoo, Peter S., Cline, Gary W., Shulman, Gerald I.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568690/
https://ncbi.nlm.nih.gov/pubmed/26305973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514844112
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